Author:
Jan Scholten
Book:
Type:
Chapter:
2-71_.__.00

Name: Herpesviridae; HHV.
Name: from the Greek herpein, to creep.

Information: large double-stranded, linear DNA genomes, encoding 100-200 genes; encased within an icosahedral protein cage called the capsid; wrapped in a lipid bilayer membrane called the envelope or virion.

Human herpesviridae
HHV-1 = HSV-1 (herpes simplex virus 1): causes oral and/or genital herpes (predominantly orofacial); B virus (Cercopithecine herpesvirus-1, herpesvirus simiae) is a simplexvirus endemic in macaque monkeys. Human zoonotic infection with this virus results in severe pathogenesis and often death in untreated individuals.
HHV-2 = HSV-2 (herpes simplex virus 2): causes oral and/or genital herpes (predominantly genital)
HHV-3 = VZV (varicella zoster virus): causes chickenpox and shingles
HHV-4 = EBV (Epstein-Barr virus), lymphocryptovirus: causes infectious mononucleosis, Burkitt's lymphoma, CNS lymphoma in AIDS, PTLD or Post-HHV-5 = CMV (cytomegalovirus): causes infectious mononucleosis, retinitis, etc.
HHV-6 = Roseolovirus: causes "sixth disease" (known as roseola infantum or exanthem subitum)
HHV-7 = closely related to HHV-6; causes roughly the same symptoms
HHV-8 = a type of rhadinovirus = KSHV = Kaposi's sarcoma-associated herpesvirus: causes Kaposi's sarcoma, primary effusion lymphoma and some types of multicentric Castleman's disease

Body
Infection: latent, lytic, recurrent.